Clinicopathologic Features Predicting HER2 Overexpression in Gastric Cancer
نویسندگان
چکیده
منابع مشابه
Clinicopathologic Features of Gastric Schwannoma
To explore the clinicopathologic characteristics, diagnosis, treatment, and prognosis of gastric schwannoma in the imatinib era.The clinicopathologic characteristics and postoperative outcomes of patients diagnosed with gastric schwannoma at our institution between January 2007 and February 2015 were retrospectively collected and analyzed.The main patient complaint was epigastric pain or discom...
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We aimed to investigate the frequency of c-erb-B2 expression rate and its association with clinicopathological parameters in our gastric carcinoma series to make a contribution to emerging data on this oncogene. One hundred thirty-nine gastric adenocarcinoma patients underwent total gastrectomy between years 2006 and 2011 were selected to the study. C-erb-B2 expressions were determined by using...
متن کامل[Immunohistochemical assessment of HER2 expression in gastric cancer. A clinicopathologic study of 93 cases].
BACKGROUND Gastric cancer in Mexico is ranked third in both males and females. Most patients present clinically with advanced disease and treatment options are sparse. HER2 overexpression in gastric cancer is related to poor outcome. Immunohistochemical testing for HER2 is becoming the standard of care for guiding adjuvant treatment of gastric cancer with trastuzumab. OBJECTIVES To determine ...
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Background: Breast cancer is one of the most prevalent malignancies among women in various countries. HER2 overexpression, which is due to different reasons, occurs in 20-30% of breast cancers. HER2 gene encodes an 185kDa transmembrane glycoprotein with 1255 amino acids. This active product triggers downstream intracellular signaling pathways inducing cell proliferation and cell survival. These...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2013
ISSN: 0923-7534
DOI: 10.1093/annonc/mdt444.2